Have you ever wondered what aspirin really does? Aspirin is one of the oldest drugs - yet we still know very little about how it functions. We know that aspirin blocks the synthesis of prostaglandins, which are lipid signaling molecules. Aspirin has many effects: Relief of inflammation and pain Stomach irritation - bleeding ulcers Reversible female infertility Cancer prevention Heart disease prevention It is unclear how aspirin causes these diverse effects, raising the question of what are the prostaglandins really doing?
CV
Friday, 05 December 2008 13:51
Tina Tootle
Tina L. Tootle
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| Assistant Professor
Department of Anatomy and Cell Bioloty
University of Iowa
Roy J. Carver College of Medicine
51 Newton Road
1-550 Bowen Science Building
Iowa City, IA 52242-1109 | Office (319) 335-7753
Fax (319) 335-7198
Home (319) 512-2727
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| Education | | 1999-2004 | Massachusetts Institute of Technology, Cambridge, MA.
PhD in Biology Mentor: Ilaria Rebay | | 1995-1998 | University of Maryland, College Park, MD. BS, Magnum Cum Laude, with High Honors in Microbiology Mentor: Jane Glazebrook |
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| Research Experience | | 2009-Present | Assistant Professor: University of Iowa, Roy J. Carver College of Medicine, Anatomy and Cell Biology, Iowa City, IA. | | 2004-2009 | Postdoctoral Fellow: Carnegie Institution, Embryology, Baltimore, MD. Mentor: Allan Spradling. | | 1999-2004 | PhD Candidate: Massachusetts Institute of Technology, Cambridge, MA. Mentor: Ilaria Rebay. | | 1999 | Research Technician: University of Maryland, Dept. Biology College Park, MD. Mentor: Soichi Tanda. | | 1996-1998 | Undergraduate Research: Center for Agricultural Biotechnology, College Park, MD. Mentor: Jane Glazebrook. |
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| Teaching Experience | | Spring 2008 | Part-time Faculty: Towson University, Towson, MD. Course: Molecular Biology (Biol409) Text: Fundamentals in Molecular Biology, Allison, Blackwell Publishing | | Spring 2003 | Teaching Assistant, Massachusetts Institute of Technology, Cambridge MA. Course: Project Lab: Molecular biology (7.17) | | Spring 2001 | Teaching Assistant, Massachusetts Institute of Technology, Cambridge MA. Course: Introductory Biology Laboratory (7.02) |
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| Awards | | 2006-Present | Ruth L. Kirschstein Postdoctoral Fellowship | | 2002-2003 | Ludwig Fellowship for Cancer Research | | 1998 | National Science Foundation Undergraduate Research Fellowship | | 1997 | Howard Hughes Undergraduate Research Fellowship | | 1995-1999 | Maryland State Scholarship – Tuition award (merit based) |
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| Publications | | 2008 | Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation. Tina Tootle and Allan Spradling. Development. 2008. 135:839-847. | | 2005 | Using Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absent. Mousumi Mutsuddi, Benjamin Chaffee, Justin Cassidy, Serena J. Silver, Tina L. Tootle, and Ilaria Rebay. Genetics. 2005. 170(2):687-95. | | 2005 | New vision from Eyes absent: transcription factors as enzymes. Ilaria Rebay, Serena Silver, and Tina Tootle. Trends in Genetics. 2005. 21(3):163-71. Review | | 2005 | Post-translational modifications influence transcription factor activity: A view from the ETS superfamily. Tina Tootle and Ilaria Rebay. Bioessays. 2005. 27(3):285-98. Review. | | 2004 | MAE, a dual regulator of the EGFR signaling pathway, is itself a target of the Ets transcription factors PNT and YAN. Pavithra Vivekanand*, Tina Tootle*, and Ilaria Rebay. Mechanisms of Development. 2004. 121(12):1469-79. | | 2003 | The transcription factor Eyes absent is a protein tyrosine phosphatase. Tina Tootle*, Serena Silver*, Erin Davies*, Victoria Newman, Robert Latek, Ishara Mills, Jeremy Selengut, Beth Parlikar, and Ilaria Rebay. Nature. 2003. 426:299-302. | | 2003 | CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE. Tina Tootle, Philina Lee, and Ilaria Rebay. Development. 2003. 130:845-857. | | 1999 | Arabidopsis PAD3, a gene required for camalexin biosynthesis, encodes a putative cytochrome p450 monooxygenase. Nan Zhou, Tina Tootle, and Jane Glazebrook. The Plant Cell. 1999. 11:2419-2428. | | 1999 | Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling. Dayadevi Jirage, Tina Tootle, Lynne Reuber, Louise Frost, Bart Feys, Jane Parker, Frederick Ausubel, and Jane Glazebrook. PNAS. 1999. 96:13583-13588. | | 1998 | PAD4 Functions Upstream from Salicylic Acid to Control Defense Responses in Arabidopsis. Nan Zhou, Tina Tootle, Frank Tsui, Daniel Klessig, and Jane Glazebrook. The Plant Cell. 1998. 10:1021-1030 | |
| (* authors contributed equally) |
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| Seminars | | 2008 | NIDDK: Laboratory of Biochemistry and Genetics – Invited Talk | | 2008 | Johns Hopkins Medical Institute Microarray Core – Invited Talk | | 2007 | University of Chicago, Dept. of Molecular Genetics and Cell Biology – Invited Talk | | 2007 | Annual Drosophila Research Conference - Session | | 2006 | Mid-Altanic Regional Society for Developmental Biology - Session | | 2004 | Annual Drosophila Research Conference - Session | | 2002 | Northeast Regional Society for Developmental Biology - Session |
Last Updated on Monday, 17 August 2009 09:08
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About Dr. Tootle 
